2. Outline
  3. Research Support Plan (2016 academic year)

Research Support Plan (2016 academic year)

(1) General Management Group

We organize a symposium for support providers and support users to share information. We organize an open lecture and a lecture for the youth as good opportunities to explain our activities for general public and the donors. In addition to meetings with other coordinated institutions, we hold cooperative meetings with other Bioresource Banks in order to promote further comprehensive cooperation of cohort study and biospecimen analysis supports in Japan.

Principal Investigator: Kohzoh Imai (Visiting Professor, the chair of the Office of Support for Platforms for Advanced Technologies and Research Resources, Institute of Medical Science, the University of Tokyo)
Co-investigators: Hideo Tanaka (Chief, Division of Epidemiology and Prevention, Aichi Cancer Center)
Yoshinori Murakami (Dean of the Institute of Medical Science, the University of Tokyo)
Support Partners: Fuyuki Ishikawa (Professor, Graduate School of Biostudies, Kyoto University)
Okio Hino (Professor, Graduate School of Medicine, Juntendo University)

(2) Group for supporting cohort study using bioresources

We formulate specific schemes and plans in order to increase the number of support. We will upload the matrix table indicating the data items that has been already stored as genotype and phenotype information to the website by August 2016 that will provide the information to the applicants. We will start to redesign the database and we will start to examine the ethical problems to upload the information in 2017 academic year because the number of clinical outcomes onset have been increased which made the disclosed information extremely valuable.

The cohort study which has completed to register 101,000 individuals as part of the “Scientific Support Programs for Cancer Research”.

  1. We continue to conduct the second survey following five years after the first survey.
  2. We continue to conduct a biennial cancer incidence survey.
  3. We continue to conduct an annual follow-up survey to trace the life and death of the donors, and the cause of death.
  4. In a part of the cohort study, we will construct a database based on the all incident information on an ischemic heart disease and a stroke obtained from the regional hospital networks or relevant institutions.
  5. We gradually will prepare to publicize the data which has been completed the analysis such as Genome Wide Association Study (GWAS) data which had registered 14,000 individuals for use as a research support.
  6. We continue to maintain the biospecimens including a blood serum in a long-term safe storage as well as in dispersed stored system in case of a large-scale natural disaster.

Brain bank:

  1. We have a brain donation coordinator to promote to obtain the consent of brain donation during their lifetime to counterpart the decrease of the autopsy ratio of the resource collection.
  2. We employ an immunohistochemically standard as a quality control of the resource.
  3. We organize to have Tokushima University and Osaka City University to join The Brain Bank for Aging Research Network.
Co-investigators: Hideo Tanaka (Chief, Division of Epidemiology and Prevention, Aichi Cancer Center)
Shigeo Murayama (Chief Researcher, Tokyo Metropolitan Institute of Gerontology)

(3) Support Group using biospecimen

We support two areas: one is to promote the bottom-up research based on the systematic understanding of biomolecular dynamics in humans in Japan covering the fields in life sciences overall, another is to facilitate the development from the basic research result to the further development of elucidating the life science phenomenon and to the applied research.

We support the analysis and methods of biomolecular dynamics and biomarker using human biospecimen. Our support includes mainly “support for analyzing supersensitive molecular pathobiology system using biospecimen, constructing a network among relevant research institutions”, and “analyzing integrative omics using biospecimen”. We conduct supersensitive molecular pathobiology system analysis using biospecimen and the various omics analysis that require our precise background information for the bio-functional molecules and biomarkers of the applicant’s interest.

We aim to conduct analysis, method, or associated support of 24 cases in total (10 or less assays each) using biospecimen under the condition of the appropriate ethic management and the division of roles. Our group is involved in collecting and providing human biospecimens in which we offer “collecting and providing human biospecimens (tissues and blood specimen) and its background information” as well as we offer “support for providing bioresouces of hematologic malignancy”. We aim to annually collect 700 cases of frozen tumor tissues and 1,000 cases of blood specimen mostly from the cancer patients, and 1,000 cases of samples from HTLV-1 infected patients.
We create a framework for pathological support organized by the expert pathologists. We aim to provide 18 cases of biospecimens (50 samples each) in total under the conditions of the appropriate ethic management and the division of roles. Also we accumulate the various test information and its analysis methods as we collect samples.
We provide four educational activities such as managing a website, organizing lectures and a conference for collecting and providing biospecimen and for providing know-how related to its use to analyses and cooperative support. We also accept trainees in the relevant institutions accordingly.

Co-investigators: Yataro Daigo (Project Professor, The Institute of Medical Science, The University of Tokyo)