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成果論文リスト

本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文にはCoBiAの課題番号「16H06277」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。

2019年度

  1. Miura K, Adachi Y, Shirahase T, Nagashima Y, Suemune K, Sakaida N, Nakano Y, Sakai Y, Shimizu S, Ikehara S.
    A case of high-grade mucinous tubular and spindle cell carcinoma. .
    J Surg Case Rep 2020(2):2020 DOI:10.1093/jscr/rjaa014
  2. Kazuya Takakuwa, Kaoru Mogushi, Min Han, Tomoaki Fujii, Masaki Hosoya, Arina Yamanami, Tomomi Akita, Chicamasa Yamashita, Shunsuke Kato, and Shigeo Yamaguchi
    A novel diagnostic system to evaluate the impact of epidermal growth factor receptor as a prognostic and therapeutic indicator for lung adenocarcinoma.
    Scientific Reports 10:2020, 6214. DOI:10.1038/s41598-020-63200-7
  3. Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D.
    A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.
    J Gynecol Oncol :2020, in press. DOI:10.3802/jgo.2020.31.e45
  4. Koyanagi YN, Suzuki E, Imoto I, Kasugai Y, Oze I, Ugai T, Iwase M, Usui Y, Kawakatsu Y, Sawabe M, Tanaka T, Abe T, Ito S, Tajika M, Ito H, Matsuo K
    Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis.
    Cancer Research 80(7):2020, 1601-1610. DOI:10.1158/0008-5472.CAN-19-2685
  5. Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
    Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells.
    Blood adv 4(9):2020, 1845-1858. DOI:10.1182/bloodadvances.2019001139
  6. Kawakita D, Abdelaziz S, Chen Y, Rowe K, Snyder J, Fraser A, Smith K, Herget K, Deshmukh V, Newman M, Monroe M, Hashibe M.
    Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study.
    Cancer 126(4):2020, 879-885. DOI:10.1002/cncr.32617
  7. Nagaoka A, Kunii Y, Hino M, Izumi R, Nagashima C, Takeshima A, Sainouchi M, Nawa H, Kakita A, Yabe H.
    ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism.
    J Psychiatr Res 123:2020, 119-127. DOI:10.1016/j.jpsychires.2020.02.001
  8. Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, Hebert JR, Tamakoshi A.
    Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study.
    Nagoya J Med Sci 82:2020
  9. Furuya M, Hasumi H, Yao M, Nagashima Y.
    Birt-Hogg-Dube syndrome-associated renal cell carcinoma: Histopathological features and diagnostic conundrum. .
    Cancer Sci 111:2020, 15-22. DOI:10.1111/cas.14255
  10. Roberts JA, Varma VR, Huang CW, An Y, Oommen A, Tanaka T, Ferrucci L, Elango P, Takebayashi T, Harada S, Iida M, Thambisetty M.
    Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS).
    International journal of molecular sciences 21:2020, E1249. DOI:10.3390/ijms21041249
  11. Camargo MC, Kim KM, Matsuo K, Torres J, Liao LM, Morgan D, Michel A, Waterboer T, Song M, Gulley ML, Pawlita M, Rabkin CS.
    Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer.
    Cancer Epidemiol Biomarkers Prev 29:2020, 414-419. DOI:10.1158/1055-9965.EPI-19-0790
  12. Nakahata S, Syahrul C, Morishita K. et al
    Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.
    Haematologica :2020, in press. DOI:10.3324/haematol.2019.234096
  13. Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwata
    Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies.
    Brain Sciences 10(1):2020, E7. DOI:10.3390/brainsci10010007
  14. Okada R、Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Kuriki K, Wakai K, et al.
    Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.
    J Hum Hypertens 34(2):2020, 125-131. DOI:10.1038/s41371-019-0230-y
  15. Banno T, Takagi T, Kondo T, Yoshida K, Iizuka J, Okumi M, Ishida H, Morita S, Nagashima Y, Tanabe K.
    Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma.
    Int Braz J Urol 46:2020, 26-33. DOI:10.1590/S1677-5538.IBJU.2018.0716
  16. Nozaki, Y. Kato, Y. Uike, K. Yamamura, K. Kikuchi, M. Yasuda, M. Ohno, S. Horie, M. Murayama, T. Kurebayashi, N. Horigome, H.
    Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a Ryanodine Receptor Type 2 Missense Mutation.
    Circulation Journal 84:2020, 226-234. DOI:10.1253/circj.CJ-19-0720
  17. Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura K, Hasegawa M, Shiio Y.
    Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy.
    Neuropathology :2020, in press. DOI:10.1111/neup.12638
  18. Sumimoto H, Takano A, Teramoto K, Daigo Y
    Detection of neoantigen-reactive T cell clones based on the clonal expansion using next-generation sequencing of T cell receptor β complementarity-determining region 3.
    J Immunol Methods. 476:2020, 112679. DOI:10.1016/j.jim.2019.112679
  19. Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Kuriki K, wakai K, et al.
    Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.
    J Epidemiol :2020, in press. DOI:10.2188/jea.JE20190296
  20. Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T
    Distribution of endogenous normal tau in the mouse brain.
    Journal of Comparative Neurology 527:2020, 985-998. DOI:10.1002/cne.24577
  21. Kazama K, Otake J, Satoyoshi T,... ,Sasada T, Masuda M.
    Distribution of Regulatory T-Cells and Other Phenotypes of T-Cells in Tumors and Regional Lymph Nodes of Colorectal Cancer Patients.
    In Vivo. 34:2020, 849-856. DOI:10.21873/invivo.11848
  22. Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M. and Suzuki T.
    Enhanced amyloid-β generation by y-secretase complex in detergent-resistant membrane microdomain accompanied by the reduced cholesterol level.
    Human. Mol. Gene. 29:2020, 382-393. DOI:10.1093/hmg/ddz297
  23. Machida H, Iwata T, Okugawa K, Matsuo K, Saito T, Tanaka K, Morishige K, Kobayashi H, Yoshino K, Tokunaga H, Ikeda T, Shozu M, Yaegashi N, Enomoto T, Mikami M.
    Fertility-sparing trachelectomy for early-stage cervical cancer: A proposal of an ideal candidate.
    Gynecol Oncol 156(2):2020, 341-348. DOI:10.1016/j.ygyno.2019.11.021
  24. Fachal L, Aschard H, Beesley J, Matsuo K, Chenevix-Trench G, Simard J, Easton DF, Kraft P, Dunning AM.
    Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
    Nat Genet 52:2020, 56-73. DOI:10.1038/s41588-019-0537-1
  25. Kishida R, Yamagishi K, Muraki I, Sata M, Tamakoshi A, Iso H; for the JACC Study Group
    Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study.
    J Atheroscler Thromb :2020, in press. DOI:10.5551/jat.53447
  26. Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Gyorffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y.
    GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer.
    Int J Cancer. 146(5):2020, 1369-1382. . DOI:10.1002/ijc.32554
  27. Maezawa Y, Sakamaki K, Oue N, Kimura Y, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
    High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1.
    J Cancer Res Clin Oncol. 146:2020, 75-86. DOI:10.1007/s00432-019-03087-8
  28. Fukuyama M, Ohno S, Ozawa J, Kato K, Makiyama T, Nakagawa Y and Horie M.
    High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8.
    Circulation Journal 84:2020, 559-568. DOI:10.1253/circj.CJ-19-1101
  29. Sakai K, Tanikawa C, Hirasawa A, Terao C, Kamatani Y, Takahashi A, Momozawa Y, Hirata M, Kubo M, Wakai K, Matsuda K. et al.
    Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.
    Scientific Reports 10(1):2020, 1197. DOI:10.1038/s41598-020-58066-8
  30. Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Low SK, Mariapun S, Matsuda K, Matsuo K, Shu XO, Kang D, Easton DF, Simard J, Zheng W.
    Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
    Nat Commun 11:2020, 1217. DOI:10.1038/s41467-020-15046-w
  31. Kano K, Sakamaki K, Oue N, Kimura Y, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
    Impact of the ESM-1 Gene Expression on Outcomes in Stage II/III Gastric Cancer Patients Who Received Adjuvant S-1 Chemotherapy.
    In Vivo 34:2020, 461-467. DOI:10.21873/invivo.11796
  32. Tatsuhiro Terada, Tomokazu Obi, Tomoyasu Bunai, Takashi Matsudaira, Etsuji Y. Ichiro A., Masami F., Hideo Tsukada, Yasuomi Ouchi
    In vivo mitochondrial and glycolytic impairments in Alzheimer's disease.
    Neurology 94(15):2020, e1592-e1604. DOI:10.1212/WNL.0000000000009249
  33. Shinohara M, Tashiro Y, Shinohara M, Hirokawa J, Suzuki K, Onishi-Takeya M, Mukouzono M, Takeda S, Saito T, Fukumori A, Saido TC, Morishita R, Sato N.
    Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
    The FASEB Journal 34:2020, 2425-2435. DOI:10.1096/fj.201901028RR
  34. Shinohara M, Tashiro Y, Suzuki K, Fukumori A, Guojun Bu, Sato N
    Interaction between APOE genotype and diabetes in cognitive decline.
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 12:2020, e12006. DOI:10.1002/dad2.12006
  35. Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D
    Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.
    J Gynecol Oncol 31(1):2020, e18. DOI:10.3802/jgo.2020.31.e18
  36. Matsuzaki S, Klar M, Mikami M, Shimada M, Grubbs BH, Fujiwara K, Roman LD, Matsuo K.
    Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence.
    Curr Oncol Rep :2020, in press. DOI:10.1007/s11912-020-0888-x
  37. Ohashi R, Martignoni G, Hartmann A, Nagashima Y, Ajioka Y, Moch H et al.
    Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme. .
    Virchows Arch 476:2020, 409-418. DOI:10.1007/s00428-019-02710
  38. Kagari Koshi-Mano, Tatsuo Mano, Maho Morishima, Shigeo Murayama, Akira Tamaoka, Shoji Tsuji, Tatsushi Toda, Atsushi Iwata
    Neuron-specific analysis of histone modifications with post-mortem brains.
    Scientific Reports :2020, 3767. DOI:10.1038/s41598-020-60775-z
  39. Zhang W, Tarutani A, Newell K, Murzin A, Matsubara T, Falcon B, Vidal R, Garringer H, Shi Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
    Novel tau filament fold in corticobasal degeneration.
    Nature :2020, in press. DOI:10.1038/s41586-020-2043-0
  40. Takagi T, Yoshida K, Wada A, Nagashima Y, Tanabe K et al.
    Predictive factors for recurrence after partial nephrectomy for clinical T1 renal cell carcinoma: a retrospective study of 1227 cases from a single institution.
    Int J Clin Oncol 12:2020 DOI:10.1007/s10147-020-01632-x
  41. Yoshinaga S, Yamanaka T, Miyazaki H, Okuzumi A, Hiyama A, Murayama S, Nukina N.
    Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study.
    Biochem Biophys Res Commun. 522:2020, 655-661. DOI:10.1016/j.bbrc.2019.11.142
  42. Hamano T, Shirafuji N, Yen SH, Yoshida H, Kanaan NM, Hayashi K, Ikawa M, Yamamura O, Fujita Y, Kuruyama M, Nakamoto Y
    Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
    Neurobiology of Aging 89:2020, 41-54. DOI:10.1016/j.neurobiolaging.2019.12.009
  43. Kaneko K, Yatsuya H, Li Y, Uemura M, Chiang C, Hirakawa Y, Ota A, Tamakoshi K, Aoyama A.
    Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study.
    J Diabetes Investig :2020, in press. DOI:10.1111/jdi.13230
  44. Tomonobu N, Kinoshita R, Sakaguchi M.
    S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis.
    Transl Oncol 13:2020, 100753. DOI:10.1016/j.tranon.2020.100753
  45. Koyama T, Kuriyama N, Ozaki E, Tomida S, Uehara R, Kuriki K, Wakai K, et al.
    Sedentary time is associated with cardiometabolic diseases in a large Japanese population: a cross-sectional study.
    J Atheroscler Thromb :2020, in press.
  46. Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Kuriki K, Wakai K, Matsuo H, et al.
    Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically-defined gout patients.
    Ann Rheum Dis 79(5):2020, 657-665. DOI:10.1136/annrheumdis-2019-216644
  47. Sakaniwa R, Tromp J, Shirai K, Yamagishi K, Tamakoshi A, Iso H
    The association of conventionally medicated systolic and diastolic blood pressure level and mortality from cardiovascular disease: is the lower the better in high stroke population?.
    Clin Res Cardiol :2020, in press. DOI:10.1007/s00392-019-01587-8
  48. Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Kuriki K, Wakai K, et al.
    The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.
    Journal of Lipid Research 61(1):2020, 86-94. DOI:10.1194/jlr.P091546
  49. Suzuki M, Muroi A, Nojima M, Numata A, Takasaki H, Sakai R, Yokose T, Miyagi Y, Koshikawa N.
    Utility of a Reverse Phase Protein Array to Evaluate Multiple Biomarkers in Diffuse Large B-Cell Lymphoma.
    Proteomics Clin Appl. Jan;14(1):2020, e1900091. DOI:10.1002/prca.201900091
  50. Sato A, Koshikawa N, et al.
    Vasoactive Intestinal Peptide Derived from Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts.
    Hepatology Communications 24;4(2):2020, 235-254. DOI:10.1002/hep4.1459
  51. Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., (他21名) , Okazawa, H.
    YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology.
    Nature Communications 11:2020, 507. DOI:10.1038/s41467-020-14353-6
  52. 成松宏人
    ゲノム研究の進歩とがん検診 -今までの道のりと未来への期待-.
    日本がん検診・診断学会誌 27:2020, 134-7.
  53. Fukuda H, Kato I, Furuya M, Tanaka R, Takagi T, Kondo T, Nagashima Y.
    A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion. .
    Virchows Arch 474:2019, 389-393. DOI:10.1007/s00428-018-2509-8
  54. Takayama K, Ohno S, Ding WG, Ashihara T, Fukumoto D, Wada Y, Makiyama T, Kise H, Hoshiai M, Matsuura H and Horie M.
    A de novo gain-of-function KCND3 mutation in early repolarization syndrome.
    Heart Rhythm 16:2019, 1698-1706. DOI:10.1016/j.hrthm.2019.05.033
  55. Ono CT, Yu Z, Kikuchi Y, Kunii Y, Hino M, Matsumoto J, Nagaoka A, Ito J, Iwasaki Y, Hagihara H, Miyakawa T, Yoshida M, Saito Y, Yabe H, Kakita A, Tomita H.
    A minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric postmortem brain studies.
    Psychiatry Clin Neurosci 73(9):2019, 566-573. DOI:10.1111/pcn.12863
  56. Li Y, Eshak ES, Kokoro S, Liu K, Jy D, Iso H, Tamakoshi A
    Alcohol consumption and risk of gastric cancer: The Japan Collaborative Cohort study.
    J Epidemiol. :2019, in press. DOI:10.2188/jea.JE20190304
  57. Takahashi Y, Uchino A, Shioya A, Sano T, Matsumoto C, Numata-Uematsu Y, Nagano S, Araki T, Murayama S, Saito Y.
    Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS.
    Neuropathology 39(4):2019, 268-278. DOI:10.1111/neup.12558
  58. Eshak ES, Iso H, Muraki I, Tamakoshi A.
    Among the water-soluble vitamins,dietary intakes of vitamins C, B2 and folate are associated with the reduced risk of diabetes in Japanese women but not men.
    Br J Nutr. 121:2019, 1357-136. DOI:10.1017/S000711451900062X
  59. Haraguchi N, Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Uehara R, Watanabe Y.
    Assessment of anthropometric indices other than BMI to evaluate arterial stiffness.
    Hypertens Res. 42:2019, 1599-1605. DOI:10.1038/s41440-019-0264-0
  60. Matsuo N, Azuma K, Sasada T.
    Assessment of soluble immune mediators as potential biomarkers during immune checkpoint inhibitor therapy.
    Oncotarget 10:2019, 1866-1867. DOI:10.18632/oncotarget.26749
  61. Fujii R, Hishida A, Furusyo N, Tanaka K, Suzuki S, Kuriyama N, Takezaki T, Arisawa K, Takashima N, Kuriki K, Mikami H, Oze I, Kubo M, Wakai K
    Association of genetic risk score and chronic kidney disease in a Japanese population.
    Nephrology (Carlton) 24(6):2019, 670-673. DOI:10.1111/nep.13479
  62. Matsuo K, Shimada M, Yamaguchi S, Matoda M, Nakanishi T, Kikkawa F, Ohmichi M, Okamoto A, Sugiyama T, Mikami M.
    Association of Radical Hysterectomy Surgical Volume and Survival for Early-Stage Cervical Cancer.
    Obstet Gynecol 133(6):2019, 1086-1098. DOI:10.1097/AOG.0000000000003280
  63. Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Maeda K, Hashimoto S, Suzuki K.
    Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population.
    Am J Clin Nutr 110:2019, 1213-1219. DOI:10.1093/ajcn/nqz181
  64. Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Keisuke Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K.
    Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney disease in a Japanese population.
    J Epidemiol 30(4):2019, 177-182. DOI:10.2188/jea.JE20180233
  65. Ukawa S, Zhao W, Yatsuya H, Yamagishi K, Tanabe N, Iso H, Tamakoshi A.
    Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study.
    J Epidemiol. 29(6):2019, 233-237. DOI:10.2188/jea.JE20170341
  66. Iwasaki Y, Arisawa K, Tanaka K, Takezaki T, Ozaki E, Koyama T, Suzuki S, Kuriki K, Kadota A, Ikezaki H, Furusyo N, Oze I, Ito H, Mikami H, Wakai K
    Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study.
    Nutrients 11:2019, 990. DOI:10.3390/nu11050990
  67. Mahajan UV, Varma VR, Huang CW, An Y, Tanaka T, Ferrucci L, Takebayashi T, Harada S, Iida M, Legido-Quigley C, Thambisetty M.
    Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts.
    International journal of molecular sciences 21:2019, E1324. DOI:10.3390/ijms21041324
  68. Yamagishi K, Sawachi S, Tamakoshi A, Iso H.
    Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women:the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).
    J Hypertens. 37:2019, 1366-1371. DOI:10.1097/HJH.0000000000002073
  69. Crotti L, Spazzolini C, Horie M, Ohno S, Wilde AAM, Wojciak J, George AL, Ackerman MJ and Schwartz PJ, et al.
    Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.
    European Heart Journal 40:2019, 2964-2975. DOI:10.1093/eurheartj/ehz311
  70. Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T6, Morimoto C, Hino O, Orimo A.
    CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers.
    Cancer Med. 8(8):2019, 3936-3948. DOI:10.1002/cam4.2249
  71. Mochizuki M, Takano A, Daigo Y, Tamai K.
    CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma.
    Lab Invest. 9(9):2019, 1349-1362. DOI:10.1038/s41374-019-0246-5
  72. Makiyama J, Kobayashi S, Watanabe E, Ishigaki T, Kawamata T, Nakashima M, Yamagishi M, Nakano K, Tojo A, Watanabe T, Uchimaru K.
    CD4+ CADM1+ cell percentage predicts disease progression in HTLV-1 carriers and indolent adult T-cell leukemia/lymphoma.
    Cancer Science 110:2019, 3746-3753. DOI:10.1111/cas.14219
  73. Hino K, Udagawa J, et al.
    Change in Brain Plasmalogen Composition by Exposure to Prenatal Undernutrition Leads to Behavioral Impairment of Rats.
    J Neurosci 39:2019, 7689-7702. DOI:10.1523/JNEUROSCI.2721-18.2019
  74. Nishio S, Matsuo K, Shibata T, Yamaguchi S, Kanao H, Takehara K, Kado N, Tozawa A, Tokunaga H, Matsunaga T, Kato H, Horie K, Kikuchi A, Enomoto T, Mikami M
    Changes in the Clinicopathological Demographics of Vulvar Cancer in Japan: Increasing Oldest-Old, Stage Shifting, and Decreasing Cohort-Level Survival †.
    J Clin Med :2019, in press. DOI:10.3390/jcm8122081
  75. Shiro Koizume, Tomoko Takahashi, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Wolfram Ruf, Katsuya Takenaka, Etsuko Miyagi, Yohei Miyagi
    Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles.
    Thrombosis and Haemostasis 119:2019, 1058 - 1071. DOI:10.1055/s-0039-1687876
  76. Ohashi R, Schraml P, Angori S, Nagashima Y, Ajioka Y, Moch H et al.
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    Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts.
    Oncol Res 27:2019, 945-956. DOI:10.3727/096504019X15555408784978
  155. Yamamoto R, Sekiyama K, Higuchi T, Ikeda M, Mikami M, Kobayashi Y, Nagase S, Yokoyama M, Enomoto T, Katabuchi H.
    Value and limitation of conization as a diagnostic procedure for cervical neoplasm.
    J Obstet Gynaecol Res 45(12):2019, 2419-2424. DOI:10.1111/jog.14118
  156. 山岸良匡,磯博康
    一般住民における降圧薬治療の有無別に見た血圧と循環器疾患死亡との関連.
    血圧 26:2019, 726-727.
  157. 諏訪園秀吾
    沖縄型神経原性筋萎縮症の自然史―2019年における臨床研究の現状.
    沖縄県医師会報 55:2019, 1022-1026.
  158. 山岸良匡
    魚摂取と大動脈疾患死亡リスク.
    医学のあゆみ 270:2019, 1214-1215.
  159. 齋藤義信,田島敬之,柴知里,小熊祐子
    身体活動促進のためのポピュレーションアプローチ:ふじさわプラス・テンの取り組み.
    日本健康教育学会誌 27:2019, 71-81. DOI:10.11260/kenkokyoiku.27.71

2018年度

  1. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K,* Orimo A.
    Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.
    International Journal of Cancer, published as early view. 146(9):2547-2562, 2020. DOI:10.1002/ijc.32672
  2. Shinohara M, Shinohara M, Zhao J, Fu Y, Liu C C, Kanekiyo T, Bu G.
    5-HT3 Antagonist Ondansetron Increases ApoE Secretion by Modulating the LXR-ABCA1 Pathway.
    Int. J. Mol. Sci 20(6):1488, 2019. DOI:10.3390/ijms20061488
  3. Shimanoe C, Hachiya T, Hara M, Nishida Y, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Kawai S, Okada R, Suzuki S, Watanabe M, Kuriki K, Endoh K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K et al.
    A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.
    Genes, Brain and Behavior 18(2):e12481, 2019. DOI:10.1111/gbb.12481
  4. Baghdadi M, Ishikawa K, Nakanishi S, Murata T, Umeyama Y, Kobayashi T, Kameda Y, Endo H, Wada H, Bogen B, Yamamoto S, Yamaguchi K, Kasahara I, Iwasaki H, Takahata M, Ibata M, Takahashi S, Goto H, Teshima T, Seino K
    A role for IL-34 in osteolytic disease of multiple myeloma.
    Blood advances 3(4):541-551, 2019. DOI:10.1182
  5. Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
    ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.
    Neurosci Res 147:48-57, 2019. DOI:10.1016/j.neures.2018.11.005
  6. Kamoi K, Okayama A, Izumo S, Hamaguchi I, Uchimaru K, Tojo A, Ohno-Matsui K.
    Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations: Analysis of the First Large-Scale Nationwide Survey.
    Front Microbiol. 9:3240, 2019. DOI:10.3389/fmicb.2018.03240
  7. Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T.
    APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1.
    J Clin Invest 129(3):1272-1277, 2019. DOI:10.1172/JCI124853
  8. Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
    Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor.
    Int J Cancer. 144(5):1170-1179, 2019. DOI:10.1002/ijc.31923
  9. Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K.
    Association of genetic risk score and chronic kidney disease in a Japanese population.
    Nephrology (Carlton) 24(6):670-673, 2019. DOI:10.1111/nep.13479
  10. Suzuki W, Wuren, Kuriki K.
    Associations between family factors and body weight gain from 20 years old.
    BMC Women’s Health. 19(1):33, 2019. DOI:10.1186/s12905-019-0719-0
  11. Ukawa S, Zhao W, Yatsuya H, Yamagishi K, Tanabe N, Iso H, Tamakoshi A.
    Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study.
    J Epidemiol 29(6):233-237, 2019. DOI:10.2188/jea.JE20170341
  12. Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K
    Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: the Yakumo Study.
    Archives of Gerontology and Geriatrics 82:155-160, 2019. DOI:10.1016/j.archger.2019.01.007
  13. Yamagishi K, Sawachi S, Tamakoshi A, Iso H
    Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).
    J Hypertens 37(7):1366-1371, 2019. DOI:10.1097/HJH.0000000000002073
  14. Naruse H,?Ishiura H, Mitsui J, Takahashi Y, Matsukawa T, Tanaka M, Doi K, Yoshimura J, Morishita S, Goto J, Toda T, Tsuji S.
    Burden of rare variants in causative genes for amyotrophic lateral sclerosis (ALS) accelerates age at onset of ALS.
    J Neurol Neurosurg Psychiatry. 90(5):537-542, 2019. DOI:10.1136/jnnp-2018-318568
  15. Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Morimoto T, Hino O, Orimo A.
    CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers.
    Cancer Med. 8:3936-3948, 2019. DOI:10.1002/cam4.2249
  16. Mai Mochizuki, Mao Nakamura, Rie Sibuya, Toshimasa Okazaki, Jiro Abe, Takayuki Nakagawa, Satomi Takahashi, Tomoko Yamazaki, Takayuki Imai, Atsushi Takano, Hiroyuki Ito, Tomoyuki Yokose, Yohei Miyagi, Yataro Daigo, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura, Kazunori Yamaguchi, Keiichi Tamai
    CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma.
    Laboratory Investigation 99(9):1349-1362, 2019. DOI:10.1038/s41374-019-0246-5
  17. Yamashita T, Kwak S
    Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.
    Neurosci Res 144:4-13, 2019. DOI:10.1016/j.neures.2018.06.004
  18. (20) Tago T, Toyohara J, Harada R, Furumoto S, Okamura N, Kudo Y, Takahashi-Fujigasaki J, Murayama S, Ishii K.
    Characterization of the binding of tau imaging ligands to melanine-containing cells: putative off-target-binding site.
    Ann. Nucl. Med. 33(6):375-382, 2019. DOI:10.1007/s12149-019-01344-x
  19. Ishikawa M, Osaki M, Yamagishi M, Onuma K, Ito H, Okada F, Endo H
    Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth.
    Oncogene 38(24):4715-4728, 2019. DOI:10.1038/s41388-019-0748-z
  20. H. Yoda, T. Inoue, Y. Shinozaki, J. Lin, T. Watanabe, N. Koshikawa, A. Takatori, H. Nagase
    Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma.
    Cancer Research 79(4):830-840, 2019. DOI:10.1158/0008-5472.CAN-18-1198
  21. Wuren, Endoh K, Kuriki K, Shizuoka-Sakuragaoka J-MICC Study group.
    Eating rate as risk for body mass index and waist circumference obesity with appropriate confounding factors: a cross-sectional analysis of the Shizuoka-Sakuragaoka J-MICC Study.
    Asia Pac J Clin Nutr 28(1):79-91, 2019. DOI:10.6133/apjcn.201903_28(1).0012
  22. J. Lin, S. Krishnamurthy, H. Yoda, Y. Shinozaki, T. Watanabe, N. Koshikawa, A. Takatori, P. Horton, H. Nagase
    Estimating genome-wide off-target effects for pyrrole-imoidazole polyamide binding by a pathway-based expression profiling approach.
    PLoS ONE 14(4):e0215247, 2019. DOI:10.1371/journal.pone.0215247
  23. Takahira Shirahase,Yoshihisa Watanabe,Atsushi Tsujimura,Shin Kwak,Toshiro Yamamoto,Narisato Kanamura and Masaki Tanaka
    Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens.
    Front.Behav.Neurosci 12:331, 2019. DOI:10.1.10.3389/fnbeh.2018.00331
  24. Yamagishi K, Iso H, Shimazu T, Tamakoshi A, Sawada N, Matsuo K, Ito H, Wakai K, Nakayama T, Kitamura Y, Sado J, Tsuji I, Sugawara Y, Mizoue T, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Sasazuki S
    Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium.
    Clin Nutr 38(4):1678-1683, 2019. DOI:10.1016/j.clnu.2018.08.007
  25. Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M, Wakai K.
    Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: A reconfirmation by the J-MICC Daiko Study.
    Nagoya Journal of Medical Science :in press, 2019.
  26. Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin T C, Takashima N, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S
    Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population.
    Sleep 42(6):zsz046, 2019. DOI:10.1093/sleep/zsz046
  27. Lawrenson K, Song F, Hazelett DJ, Kar SP, Tyrer J, Phelan CM, Corona RI, Rodr?guez-Malav? NI, Seo JH, Adler E, Coetzee SG, Segato F, Fonseca MAS, Amos CI, Carney ME, Chenevix-Trench G, Choi J, Doherty JA, Jia W, Jin GJ, Kim BG, Le ND, Lee J, Li L, Lim BK, Adenan NA, Mizuno M, Park B, Pearce CL, Shan K, Shi Y, Shu XO, Sieh W; Australian Ovarian Cancer Study Group, Thompson PJ, Wilkens LR, Wei Q, Woo YL, Yan L, Karlan BY, Freedman ML, Noushmehr H, Goode EL, Berchuck A, Sellers TA, Teo SH, Zheng W, Matsuo K, Park S, Chen K, Pharoah PDP, Gayther SA, Goodman MT.
    Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
    Gynecol Oncol :30133-30137, 2019. DOI:10.1016/j.ygyno.2019.02.023
  28. Takeuchi F, Kukimoto I, Li Z, Li S, Li N, Hu Z, Takahashi A, Inoue S, Yokoi S, Chen J, Hang D, Kuroda M, Matsuda F, Mizuno M, Mori S, Wu P, Tanaka N, Matsuo K, Kamatani Y, Kubo M, Ma D, Shi Y.
    Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.
    Hum Mol Genet 28(2):341-348, 2019. DOI:10.1093/hmg/ddy390
  29. Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H (他38名)
    Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.
    Communications Biology 2:115, 2019. DOI:10.1038/s42003-019-0339-0
  30. Asahi Hishida, Tomotaka Ugai, Ryosuke Fujii, Masahiro Nakatochi, et al.
    GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy. (ピロリ菌関連萎縮性胃炎についてのGWAS研究).
    Carcinogenesis 40(5):661-668, 2019. DOI:10.1093/carcin/bgz016
  31. Hino K, Kimura T, Udagawa J
    Handling has an anxiolytic effect that is not affected by the inhibition of the protein kinase C pathway in adult prenatal undernourished male rat offspring.
    Congenit Anom :in press, 2019. DOI:10.1111/cga.12332
  32. Suzuki K, Akiyama M, Horikoshi M, Kamatani Y, Hosoe J, Shojima N, Ishigaki K, Kanai M, Atsushi H, Kadota A, Kuriki K, Naito M, Tannno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Okada Y, Maeda S, Murakami Y, Wakai W, Tsugane S, Sasaki M, Yamamoto M, Kubo M, Yamauchi T, Kadowaki T.
    Identification of 28 novel susceptibility loci for type 2 diabetes in the Japanese population.
    Nat Genet. 51(3):379-386, 2019. DOI:10.1038/s41588-018-0332-4
  33. Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
    Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
    Diabetes 68(3):617-630, 2019. DOI:10.1124/jpet.118.253922
  34. Aizawa H, Yamashita T, Kato H, Kimura T, Kwak S
    Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein.
    J Clin Neurol 15(1)::62-67, 2019. DOI:10.3988/jcn.2019.15.1.62
  35. Hirokazu Uemura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kenji Wakai, et al. for the Japan Multi-institutional Collaborative Cohort Study Group.
    Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.
    Endocrine 64:552-563, 2019. DOI:10.1007/s12020-019-01926-9
  36. Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
    Intensity-specific and modified effects of physical activity on serum adiponectin in a middle-aged population.
    Journal of the Endocrine Society 3(1):13-26, 2019. DOI:10.1210/js.2018-00255
  37. Lu Y, Kweon SS, Tanikawa C, Jia WH, Xiang YB, Cai Q, Zeng C, Schmit SL, Shin A, Matsuo K, Jee SH, Kim DH, Kim J, Wen W, Shi J, Guo X, Li B, Wang N, Zhang B, Li X, Shin MH, Li HL, Ren Z, Oh JH, Oze I, Ahn YO, Jung KJ, Conti DV, Schumacher FR, Rennert G, Jenkins MA, Campbell PT, Hoffmeister M, Casey G, Gruber SB, Gao J, Gao YT, Pan ZZ, Kamatani Y, Zeng YX, Shu XO, Long J, Matsuda K, Zheng W.
    Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
    Gastroenterology 156(5):1455-1466, 2019. DOI:10.1053/j.gastro.2018.11.066
  38. (21) Tago T, Toyohara J, Sengoku R, Murayama Y, Ishii K.
    MAO-B binding of 18F-THK5351 to visualize glioblastoma and associated gliosis: an autopsy-confirmed case.
    Cln. Nucl. Med. 44(6):507-509, 2019. DOI:10.1097/RLU.0000000000002564
  39. Asahi Hishida, Ryosuke Watanabe, Yuta Hattori, Yoshinaga Okugawa,
    No substantial effect of polymorphisms in CPT1B and CPT2 on plasma carnitine levels in Japanese. (CPT遺伝子多型と血漿カルニチン濃度に関する研究).
    Nagoya J Med Sci 81(3):477-187, 2019. DOI:10.18999/nagjms.81.3.477
  40. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Kono S, Kooperberg C, Krogh V, Kuehn T, K?ry S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, Levine D, Li CI, Li L, Lieb W, Lin Y, Lindor NM, Liu YR, Loupakis F, Lu Y, Luh F, Ma J, Mancao C, Manion FJ, Markowitz SD, Martin V, Matsuda K, Matsuo K, McDonnell KJ, McNeil CE, Milne R, Molina AJ, Mukherjee B, Murphy N, Newcomb PA, Offit K, Omichessan H, Palli D, Cotor? JPP, P?rez-Mayoral J, Pharoah PD, Potter JD, Qu C, Raskin L, Rennert G, Rennert HS, Riggs BM, Schafmayer C, Schoen RE, Sellers TA, Seminara D, Severi G, Shi W, Shibata D, Shu XO, Siegel EM, Slattery ML, Southey M, Stadler ZK, Stern MC, Stintzing S, Taverna D, Thibodeau SN, Thomas DC, Trichopoulou A, Tsugane S, Ulrich CM, van Duijnhoven FJB, van Guelpan B, Vijai J, Virtamo J, Weinstein SJ, White E, Win AK, Wolk A, Woods M, Wu AH, Wu K, Xiang YB, Yen Y, Zanke BW, Zeng YX, Zhang B, Zubair N, Kweon SS, Figueiredo JC, Zheng W, Marchand LL, Lindblom A, Moreno V, Peters U, Casey G, Hsu L, Conti DV, Gruber SB.
    Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
    J Natl Cancer Inst 111(2):146-157, 2019. DOI:10.1093/jnci/djy099
  41. Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
    NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.
    J Gerontol A Biol Sci Med Sci. :in press, 2019. DOI:10.1093/gerona/gly282
  42. Yoko?Kataoka, Tomoyuki?Igarashi, Yasuhiko?Ohshio, Takuya?Fuji, Jun?Hanaoka
    Predictive importance of?galectin-3 for?recurrence of?non-small cell lung cancer .
    General Thoracic and Cardiovascular Surgery 67:704-711, 2019. DOI:10.1007/s11748-019-01074-x
  43. Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T.
    Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
    J Clin Oncol. 37:JCO1800501, 2019. DOI:10.1200/JCO.18.00501
  44. Nishida Y, Kubota Y, Iso H, Tamakoshi A
    Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study.
    J Atheroscler Thromb , 2019. DOI:10.5551/jat.46383
  45. Cao J, Eshak ES, Liu K, Muraki I, Cui R, Iso H, Tamakoshi A.
    Sleep duration and risk of breast cancer: The JACC Study.
    Breast Cancer Res Treat 174(1):219-225, 2019. DOI:10.1007/s10549-018-4995-4
  46. Masaki Nishioka, Miki Bundo, Kazuya Iwamoto, Tadafumi Kato
    Somatic mutations in the human brain: implications for psychiatric research.
    Molecular Psychiatry 24(6):839-856, 2019. DOI:10.1038/s41380-018-0129-y
  47. Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.
    Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.
    Life Science Alliance 2:e201900425., 2019. DOI:10.26508/lsa.201900425
  48. Ikehara S, Iso H, Maruyama K, Ukawa S, Tamakoshi A; Japan Collaborative Cohort Study.
    Television viewing time, walking time, and risk of type 2 diabetes in Japanese men and women: The Japan Collaborative Cohort Study.
    Prev Med 118:220-225, 2019. DOI:10.1016/j.ypmed.2018.11.006
  49. Watanabe S, Konta T, Ichikawa K, Watanabe M, Ishizawa K, Ueno Y, Yamashita H, Kayama T, Kubota I.
    The association between urinary sodium excretion and blood pressure in a community-based population: the Yamagata (Takahata) study.
    Clinical and Experimental Nephrology 23:380-386, 2019. DOI:10.1007/s10157-018-1654-3
  50. Eshak ES, Maruyama K, Iso H, Tamakoshi A.
    The Prospective Association Between Plasma Concentrations of Cellular Growth Factors and Risk of Heart Failure Mortality in Japanese Population.
    J Epidemiol 29:104-109, 2019. DOI:10.2188/jea.JE20170123
  51. Yuta Murakami, Kiyoshi Saito, Hiromi Ito, Yasuhiro Hashimoto
    Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases.
    Proceedings of the Japan Academy, Series B 95(5):198-210, 2019. DOI:10.2183/pjab.95.015
  52. Iwaya H, Hijioka S, Mizuno N,Kuwahara T, Okuno N, Tajika M, Tanaka T, Ishihara M Hirayama Y, Onishi S, Ito A, Kuraoka N,Matsumoto S, Polmance P, Shimizu Y,
    Usefulness of septal thickness measurement on endoscopic ultrasound as a predictor of malignancy of branched-duct and mixed-type intraductal papillary mucinous neoplasm of the pancreas.
    Dig.Endosc 31:672-681, 2019. DOI:10.1111/den.13408
  53. Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y
    Visualization of Amyloid beta Deposits in Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.
    Journal of Visualized Experiment :145, 2019. DOI:10.3791/57645
  54. Hasumi H, Furuya M, Tatsuno K, Nagashima Y, Metwalli AR, Schmidt LS, Aburatani H, Linehan WM, Yao M et al.
    BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes. .
    Hum Mol Genet 27:2712-2724, 2018. DOI:10.1093/hmg/ddy181
  55. Yasukawa S, Eguchi E, Ogino K, Tamakoshi A, Iso H.
    "Ikigai", Subjective Wellbeing, as a Modifier of the Parity-Cardiovascular Mortality Association?- The Japan Collaborative Cohort Study.
    Circ J 82(5):1302-1308, 2018. DOI:10.1253/circj.CJ-17-1201
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    Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy.
    Acta Neuropathol Commun. 6:53, 2018. DOI:10.1186/s40478-018-0556-7
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    New Model for Predicting Malignancy in Patients With Intraductal Papillary Mucinous Neoplasm.
    Ann Surg 29:30499803, 2018. DOI:10.1097/SLA.0000000000003108
  117. Yasuoka S, Hamasaki T, Kuribayashi E, Nagasawa M, Kawaguchi T, Nagashima Y, Kondo Y.
    Nivolumab therapy for metastatic collecting duct carcinoma after nephrectomy: A case report.
    Medicine (Baltimore) 97:e13173, 2018. DOI:10.1097/MD.0000000000013173
  118. Satoru Morimoto, Hiroyuki Hatsuta , Yasumasa Kokubo, Hiroyuki Ishiura , Shoji Tsuji , Shigeki Kuzuhara, Shigeo Murayama
    Optineurin Pathology in the Spinal Cord of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Patients in Kii peninsula, Japan.
    Brain Pathology 28:422-426, 2018. DOI:10.1111/bpa.12558
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    Pathological alterations of chondroitin sulfate moiety in postmortemhippocampus of patients with schizophrenia.
    Psychiatry Research 270:940-946, 2018. DOI:10.1016/j.psychres.2018.10.062
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    Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration.
    Neuropathology 38:171-178, 2018. DOI:10.1111/neup.12430
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    Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma.
    Biomark Res 6, 2018. DOI:10.1186/s40364-018-0138-7
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    Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.
    Acta Neuropathol Commun 6:29, 2018. DOI:10.1186/s40478-018-0532-2
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    Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.
    Journal of Clinical and Experimental Hematology 58(4):152-160, 2018. DOI:10.3960/jslrt.18034
  124. Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo K.
    Prediction model for pancreatic cancer risk in the general Japanese population.
    PLoS ONE 13(9):e0203386, 2018. DOI:10.1371/journal.pone.0203386
  125. 片岡圭亮、渡邉俊樹、小川誠司
    Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.
    Blood 131(2):215-225, 2018. DOI:10.1182/blood-2017-01-761874
  126. Fukuda H, Takagi T, Kondo T, Yoshida K, Shimizu S, Nagashima Y, Tanabe K.
    Prognostic value of the Glasgow Prognostic Score for patients with metastatic renal cell carcinoma treated by cytoreductive nephrectomy. .
    Int J Clin Oncol. 23:539-546, 2018. DOI:10.1007/s10147-017-1221-z
  127. Takao M, Kimura H, Kitamoto T,?Mihara B.
    PrPres?deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases (CJD).
    Acta Neuropathol Commun. 6:78, 2018. DOI:10.1186/s40478-018-0582-5
  128. Higashihara M, Sonoo M, Ishiyama A, Nagashima Y, Matsumoto K, Uesugi H, et al.
    Quantitative Analysis of Surface Electromyography for Pediatric Neuromuscular Disordersの研究.
    Muscle Nerve 58(6):824-827, 2018. DOI:10.1002/mus.26299
  129. Senda Y, Shimizu Y, Natsume S, Ito S, Komori K, Abe T, Matsuo K, Sano T
    Randomized clinical trial of duct-to-mucosa versus invagination pancreaticojejunostomy after pancreatoduodenectomy.
    Br J Surg 105:48-57, 2018. DOI:10.1002/bjs.10727
  130. Yuta Murakami, Yuka Matsumoto, Kyoka Hoshi, Hiromi Ito, Takashi J. Fuwa, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Kenneth Nollet, Naho Kato, Rie Nishikata, Naohito Kuroda, Takashi Honda, Jun Sakuma, Kiyoshi Saito, Yasuhiro Hashimoto
    Rapid increase of "brain-type" transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery.
    Journal of Biochemistry 164:206-213, 2018. DOI:10.1093/jb/mvy043
  131. Terada T, Miyata J, Obi T, Kubota M, Yoshizumi M, Murai T.
    Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease.
    J Neurol Sci 390:231-238, 2018. DOI:10.1016/j.jns.2018.05.005
  132. Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A
    Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease: The Japan Collaborative Cohort Study.
    Stroke 49(2):454-457, 2018. DOI:10.1161/STROKEAHA.117.019417
  133. Tsuboi Y, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Murase Y, Ohashi K, Ishikawa H, Kondo M, Inoue T, Hashimoto S, Hamajima N, Suzuki K.
    Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population.
    Journal of atherosclerosis and thrombosis 25(12):1231-1239, 2018. DOI:10.5551/jat.43570
  134. Ohtsuka T, Gotoh Y, Nakashima Y, Okayama Y, Nakamura S, Morita M, Aly MYF, Velasquez VVDM, Mori Y, Sadakari Y, Nakata K, Miyasaka Y, Ishigami K,et al
    Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct.
    Pancreatology 18:566-571, 2018. DOI:10.1016/j.pan.2018.04.012
  135. Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, *Okazawa H.
    Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology.
    eNeuro 5(4):0217-18, 2018. DOI:10.1523/ENEURO.0217-18.2018
  136. Yoh T, Hatano E, Kasai Y, Fujii H, Nishi K, Toriguchi K, Sueoka H, Ohno M, Seo S, Iwaisako K, Taura K, Yamaguchi R, Kurokawa M, Fujimoto J, Kimura T, Uemoto S, and Nishi E.
    Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection.
    Clinical Cancer Research :Epub ahead of print, 2018. DOI:10.1158/1078-0432.CCR-18-0124
  137. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K.
    Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease.
    PNAS USA 115 (25):E5815-E5823, 2018. DOI:10.1073/pnas.1802179115
  138. Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Masakazu Miyajima, Hajime Arai, Yasuhiro Hashimoto, Tatsuo Mima
    Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.
    BBA General Subjects 1862:1835-1842, 2018. DOI:10.1016/j.bbagen.2018.03.027
  139. Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
    Study on the tumor-induced angiogenesis using mathematical models.
    Cancer Science 109:15-23, 2018. DOI:10.1111/cas.13395
  140. de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
    Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
    EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024
  141. Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H
    Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
    Nat Commun. 30;9(1):433-433, 2018. DOI:10.1038/s41467-018-02821-z
  142. Shinotoh H*, Shimada H, Kokubo Y*, Tagai K, Niwa F, Kitamura S, Endo H, Ono M, Kimura Y, Hirano S, M …
    Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninusula.
    Neurology 92(2):e136-147, 2018. DOI:10.1212/WNL.0000000000006736
  143. Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K.K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M.
    TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD.
    Biol. Psychiatry 84:509-521, 2018. DOI:10.1016/j.biopsych.2018.03.008
  144. Tamura T, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Okada R, Kawai S, Hishida A, Wakai K.
    The association between self-rated health and high-sensitivity C-reactive protein level: a cross-sectional and 5-year longitudinal study.
    BMC Public Health 18(1):1380, 2018. DOI:10.1186/s12889-018-6251-6
  145. Kawakita D, Lee YA, Gren LH, Buys SS, La Vecchia C, Hashibe M.
    The impact of folate intake on the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort.
    British Journal of Cancer 118(2):299-306, 2018. DOI:10.1038/bjc.2017.383
  146. Tanaka, H., Kondo, K., Chen, X., Homma, H., Tagawa, K., Kerever, A., Aoki, S., Saito, T., Saido, T., Muramatsu, S., Fujita, K. & Okazawa, H.
    The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology.
    Molecular Psychiatry 23:2090-2110, 2018. DOI:10.1038/s41380-018-0253-8
  147. Nakashima M, Watanabe M, Uchimaru K, Horie R.
    Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling.
    Biol Cell 110(5):109-124, 2018. DOI:10.1111/boc.201800002
  148. Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K
    Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
    Cell 174(3):636-648, 2018. DOI:10.1016/j.cell.2018.06.011.?
  149. Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, et al
    Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the Kii Peninsula, Japan.
    Brain Pathol 28:287-291, 2018. DOI:10.1111/bpa.12500
  150. Earp M, Tyrer JP, Winham SJ, Lin HY, Chornokur G, Dennis J, Aben KKH, Anton-Culver H, Antonenkova N, Bandera EV, Bean YT, Beckmann MW, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bruinsma F, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, D?rk T, du Bois A, D?rst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hildebrandt MAT, Hillemanns P, Hogdall CK, H?gdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Jung AY, Karlan BY, Kellar M, Kiemeney LA, Kiong Lim B, Kjaer SK, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lele S, Lester J, Levine DA, Li Z, Liang D, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LFAG, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Moysich KB, Ness RB, Nevanlinna H, Odunsi K, Olson SH, Orlow I, Orsulic S, Paul J, Pejovic T, Pelttari LM, Permuth JB, Pike MC, Poole EM, Rosen B, Rossing MA, Rothstein JH, Runnebaum IB, Rzepecka IK, Schernhammer E, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Tangen IL, Teo SH, Terry KL, Thompson PJ, Thomsen L, Tworoger SS, van Altena AM, Vergote I, Vestrheim Thomsen LC, Vierkant RA, Walsh CS, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Woo YL, Wu AH, Wu X, Xiang YB, Yang H, Zheng W, Ziogas A, Lee AW, Pearce CL, Berchuck A, Schildkraut JM, Ramus SJ, Monteiro ANA, Narod SA, Sellers TA, Gayther SA, Kelemen LE, Chenevix-Trench G, Risch HA, Pharoah PDP, Goode EL, Phelan CM.
    Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
    PLoS ONE 13(7):e0197561, 2018. DOI:10.1371/journal.pone.0197561
  151. Cui R, Iso H, Eshak ES, Maruyama K, Tamakoshi A
    Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study.
    Public Health Nutr 21(16):3011-3017, 2018. DOI:10.1017/S1368980018001386
  152. 北川善康、奥村和弘、鈴木拓人、渡部隆義、篠崎喜脩、早田浩明、傳田忠道、山口武人、永瀬浩喜
    ピロールイミダゾール含有ポリアミドによる 大腸がん患者血液由来のKRAS 変異アレル濃縮法の検討.
    調査研究ジャーナル Vol.7 No.2:106-110, 2018.
  153. Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y, Murakami S, Matsuo K.
    喫煙と唾液腺癌リスクに関する研究.
    Cancer 124(2):118-125, 2018. DOI:10.1002/cncr.30958
  154. 栗山長門,渡邊能行.
    血管性認知症に関する疫学研究.
    京都府立医科大学雑誌 127:435-449, 2018.
  155. 村上友太、齋藤 清、高橋浩一、荒木信夫、橋本康弘
    髄液バイオマーカーとしての“脳型”トランスフェリン.
    自律神経 :in press, 2018.
  156. 村上友太、高橋浩一、星 京香、伊藤浩美、齋藤 清、宮嶋雅一、新井 一、美馬達夫、橋本康弘
    脳脊髄液減少症(特発性低髄液圧症候群)と脳型トランスフェリン.
    日本頭痛学会誌 45(1):25-33, 2018.
  157. Makoto Yamagishi, Kaoru Uchimaru
    ATL、HTLV-1キャリアに対する新規治療法の開発及び薬効評価.
    Current Opinion in Oncology 29:375-381, 2017.
  158. Kawakita D, Matsuo K, Boffetta P, Hashibe M, La Vecchia C, Edefonti V, et al.
    Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
    International Journal of Cancer 141(9):1811-1821, 2017. DOI:10.1002/ijc.30886
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    Impact of oral hygiene on head and neck cancer risk in a Chinese population.
    Head & Neck 39(12):2549-2557, 2017. DOI:10.1002/hed.24929

2017年度

  1. Eshak ES, Iso H, Muraki I, Tamakoshi A
    Fat-soluble vitamins from diet in relation to risk of type 2 diabetes mellitus in Japanese population.
    Br J Nutr 20:1-18, 2018. DOI:10.1017/S000711451800377X
  2. Okada E, Nakamura K, Ukawa S, Wakai K, Date C, Iso H, Tamakoshi A
    The Japanese food score and risk of all-cause, CVD and cancer mortality: the Japan Collaborative Cohort Study.
    Br J Nutr 120:464-471, 2018. DOI:10.1017/S000711451800154X
  3. Nakamura Y, Narita A, Hachiya T, Sutoh Y, Shimizu A, Ohno S, Takashima N, Suzuki H, Tanaka K, Hara M, Kuriki K, Endoh K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Mikami H, Nakamura Y, Shimoshikiryo I, Takezaki T, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Furusyo N, Ikezaki H, Nakatochi M, Kawai S, Hishida A, Okada R, Tamura T, Naito M, Wakai K, Momozawa Y, Kubo M, Ueshima H, Kita Y.
    A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study.
    J Clin Diabetes. 2:102, 2018.
  4. Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Oze I, Watanabe M, Matsuo K, Ito H, Hara M, Nishida Y, Endoh K, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Ibusuki R, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Wakai K, et al.
    A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study.
    Scientific Reports 8(1):1493, 2018. DOI:10.1038/s41598-018-19914-w
  5. Ukawa S, Tamakoshi A, Mori M, Ikehara S, Shirakawa T, Yatsuya H, Iso H.
    Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study.
    Cancer Causes Control 29:213-219, 2018. DOI:10.1007/s10552-018-1001-8
  6. Kuriyama Nagato, Ozaki Etsuko, Mizuno Toshiki, Ihara Masafumi, Mizuno Shigeto, Koyama Teruhide, Matsui Daisuke, Watanabe Isao, Akazawa Kentaro, Takeda Kazuo, Takada Akihiro, Inaba Masaaki, Yamada Shinsuke, Motoyama Koka, Takeshita Wakiko, Iwai Komei, Hashiguchi Kanae, Kobayashi Daiki, Kondo Masaki, Tamura Aiko, Yamada Kei, Nakagawa Masanori, Watanabe Yoshiyuki
    Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.
    J Alzheimers Dis 61(1):145-155, 2018. DOI:10.3233/JAD-170466
  7. Etsuko Ozaki, Shinsuke Yamada, Nagato Kuriyama, Daisuke Matsui, Isao Watanabe,Teruhide Koyama, Yasuo Imanishi, Masaaki Inaba & Yoshiyuki Watanabe
    Association of BAP with urinary albumin excretion in postmenopausal, but not premenopausal, non-CKDJapanese women.
    Scientific Reports 8(1):82, 2018. DOI:10.1038/s41598-017-1473-w
  8. Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K
    Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population.
    Gene 642:172-177, 2018. DOI:10.1016/j.gene.2017.11.031
  9. Liu Y, Shu XO, Wen W, Saito E, Rahman MS, Tsugane S, Tamakoshi A, Xiang YB, Yuan JM, Gao YT, Tsuji I, Kanemura S, Nagata C, Shin MH, Pan WH, Koh WP, Sawada N, Cai H, Li HL, Tomata Y, Sugawara Y, Wada K, Ahn YO, Yoo KY, Ashan H, Chia KS, Boffetta P, Inoue M, Kang D, Potter JD, Zheng W.
    Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium.
    Int J Epidemiol :Epub ahead of print, 2018. DOI:10.1093/ije/dyy024
  10. Eshak ES, Iso H, Yamagishi K, Maruyama K, Umesawa M, Tamakoshi A.
    Associations between copper and zinc intakes from diet and mortality from cardiovascular disease in a large population-based prospective cohort study.
    J Nutr Biochem 56:126-132, 2018. DOI:10.1016/j.jnutbio.2018.02.008
  11. Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.
    Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
    Int J Oncol. 52(1):155-165, 2018. DOI:10.3892/ijo.2017.4181
  12. Y. Horiuchi, J. Lin, Y. Shinojima, K. Fujiwara, M. Moriyama, H. Nagase
    Characterizing key nucleotide polymorphisms of hepatitis C virus-disease associations via mass-spectrometric genotyping.
    International Journal of Oncology 52(2):441-452, 2018. DOI:10.3892/ijo.2017.4209
  13. Kashino I, Akter S, Mizoue T, Sawada N, Kotemori A, Matsuo K, Oze I, Ito H, Naito M, Nakayama T, Kitamura Y, Tamakoshi A, Tsuji I, Sugawara Y, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Shimazu T; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
    Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan.
    Int J Cancer 143:307-316, 2018. DOI:10.1002/ijc.31320
  14. Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Sahoko Matsuoka, Reiko Tanaka, Yuetsu Tanaka, Isao Hamaguchi
    Control of HTLV-1 Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.
    Journal of Virology 92(4):e01885-17, 2018. DOI:10.1128/JVI.01885-17
  15. Shimanoe C, Hara M, Nishida Y, Nanri H, Otsuka Y, Horita M, Yasukata J, Miyoshi N, Yamada Y, Higaki Y, Tanaka K
    Coping strategy and social support modify the association between perceived stress and C-reactive protein: a longitudinal study of healthy men and women.
    Stress 21(3):237-246, 2018. DOI:10.1080/10253890.2018.1435638
  16. Eshak ES, Iso H, Yamagishi K, Cui R, Tamakoshi A.
    Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study.
    Nutrition 47:50-55, 2018. DOI:10.1016/j.nut.2017.09.009
  17. Miho Ogawa, Kazuaki Yokoyama, Mitsuhito Hirano, Koji Jimbo, Kiyosumi Ochi, Toyotaka Kawamata, Nobuhiro Ohno, Eigo Shimizu,Nozomi Yokoyama,Rui Yamaguchi,Seiya Imoto, Kaoru Uchimaru, Satoru Miyano,Yoichi Imai, Arinobu Tojo.
    Different Clonal Dynamics of Chronic Myeloid Leukaemia between Bone Marrow and the Central Nervous System.
    Journal: British Journal of Haematology. 183(5):842-845, 2018. DOI:10.1111/bjh.15065
  18. Kenichi Nagata, Tatsuo Mano, Shigeo Murayama, Takaomi C. Saido, Atsushi Iwata
    DNA methylation level of the neprilysin promoter in Alzheimer's disease brains.
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  153. Yada E, Wada S, Yoshida S, Sasada T.
    Use of patient-derived xenograft mouse models in cancer research and treatment.
    Future Sci OA. 4(3):FSO271, 2017. DOI:10.4155/fsoa-2017-0136
  154. Inoshita T, Arano T, Hosaka Y, Meng H, Umezaki Y, Kosugi S, Morimoto T, Koike M, Chang HY, Imai Y, Hattori N
    Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
    Hum Mol Genet. 26:2933-2948, 2017. DOI:10.1093/hmg/ddx179
  155. Kokubo Yasumasa、Banack Sandra Anne、Morimoto Satoru、Murayama Shigeo、Togashi Tatsuya、Metcalf James S.、Cox Paul Alan、Kuzuhara Shigeki
    β-N-methylamino-L-alanine analysis in the brains of patients with Kii ALS/PDC.
    Neurology 89:1091-1092, 2017. DOI:10.1212/wnl.0000000000004310
  156. 土田 剛行,岩田 淳
    パーキンソン病とエピジェネティクス.
    医学のあゆみ 262(6):622-626, 2017.
  157. 間野 達雄,岩田 淳
    神経変性疾患とエピジェネティクス.
    アンチエイジング医学 12(6):776-782, 2017.
  158. 間野 達雄,岩田 淳
    認知症のエピジェネティクス.
    実験医学 35(12):2030-2033, 2017.

2016年度

  1. Koyanagi YN, Matsuo K, Ito H, Tamakoshi A, Sugawara Y, Hidaka A, Wada K, Oze I, Kitamura Y, Liu R, Mizoue T, Sawada N, Nagata C, Wakai K, Nakayama T, Sadakane A, Tanaka K, Inoue M, Tsugane S, Sasazuki S.
    Body-Mass Index and Pancreatic Cancer Incidence: A Pooled Analysis of Nine Population-Based Cohort Studies With More Than 340,000 Japanese Subjects.
    J Epidemiol 28:245-252, 2018. DOI:10.2188/jea.JE20160193
  2. Endoh K, Matsui Y, Takeshita M, Katashima, Yasunaga, Kuriki K.
    Actual Daily Intakes of Tea Catechins and Their Estimation According to Four Season 3 Day Weighed Dietary Records and a Short Food Frequency Questionnaire among Japanese Men and Women.
    Asian Pac J Cancer Prev 18(10):2875-2881, 2017. DOI:10.22034/APJCP.2017.18.10.2875
  3. Chen Y, Wu F, Saito E, Lin Y, Song M, Luu HN, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Xiang YB, Tomata Y, Sugiyama K, Park SK, Matsuo K, Nagata C, Sugawara Y, Qiao YL, You SL, Wang R, Shin MH, Pan WH, Pednekar MS, Tsugane S, Cai H, Yuan JM, Gao YT, Tsuji I, Kanemura S, Ito H, Wada K, Ahn YO, Yoo KY, Ahsan H, Chia KS, Boffetta P, Zheng W, Inoue M, Kang D, Potter JD.
    Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium.
    Diabetologia 60:1022-1032, 2017. DOI:10.1007/s00125-017-4229-z
  4. Iso H, Maruyama K, Eshak ES, Ikehara S, Yamagishi K, Tamakoshi A.
    Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese: The JACC study.
    Atherosclerosis 260:97-101, 2017. DOI:10.1016/j.atherosclerosis.2017.03.020
  5. Takenari Yamashita, Hitoshi Aizawa, Sayaka Teramoto, Megumi Akamatsu & Shin Kwak
    Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.
    Scientific Reports 7:39994, 2017. DOI:10.1038/srep39994
  6. Ishii Y, Ishihara J, Takachi R, Shinozawa Y, Imaeda N, Goto C, Wakai K, Takahashi T, Iso H, Nakamura K, Tanaka J, Shimazu T, Yamaji T, Sasazuki S, Sawada N, Iwasaki M, Mikami H, Kuriki K, et al.
    Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires.
    J Epidemiol 27(7):331-337, 2017. DOI:10.1016/j.je.2016.08.008
  7. Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Sato S, Setou M, Yabe H.
    Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
    Scientific Reports 7:45050, 2017. DOI:10.1038/srep45050
  8. Fuji S, Yamaguchi T, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Owatari S, Miyagi T, Taguchi J, Choi I, Otsuka E, Nakachi S, Yamamoto H, Kurosawa S, Tobinai K, Fukuda T.
    Development of a modified prognostic index of patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: a possible risk-adapted management strategies including allogeneic transplantation.
    Haematologica 102(7):1258-1265, 2017. DOI:10.3324/haematol.2017.164996
  9. Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S
    Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.
    J Proteomics 31;158:31-42, 2017. DOI:10.1016/j.jprot.2017.02009
  10. Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saitoh, Shinobu Kitazume, Hiroyuki Hatsuda, Yuri Miura, Shinichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya and Tamao Endo
    Excess APP O-glycosylation by GalNAc-T6 decreases Ab production.
    Jourmal of Biochemistry 161:99-111, 2017. DOI:10.1093/jb/mvw056.Epub2016Oct19
  11. Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Wakai K, et al.
    Genetic predisposition to ischemic stroke: a polygenic risk score.
    Stroke 48(2):253-258, 2017. DOI:10.1161/STROKEAHA.116.014506
  12. Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, et al.
    Genetic Variants of RAMP2 and CLR are Associated with Stroke.
    J Atheroscler Thromb 24(12):1267-1281, 2017. DOI:10.5551/jat.41517
  13. Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K.
    Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
    Sci Rep 9;7:40205, 2017. DOI:10.1038/srep40205
  14. Okada R, Naito M, Hattori Y, Seiki T, Wakai K, Nanri H, Watanabe M, Suzuki S, Kairupan T, Takashima N, Mikami H, Ohnaka K, Watanabe Y, Katsuura-Kamano S, Kubo M, Hamajima N, Tanaka H, The Japan Multi-institutional Collaborative Cohort Study Group
    Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer.
    Gastric Cancer 20(2):246-253, 2017. DOI:10.1007/s10120-016-0608-2
  15. Ukawa S, Tamakoshi A, Yatsuya H, Yamagishi K, Ando M, Iso H.
    Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study.
    Int J Public Health 62:489-494, 2017. DOI:10.1007/s00038-016-0938-1
  16. Kikuchi N, Nishiyama T, Sawada T, Wang C, Lin Y, Watanabe Y, Tamakoshi A, Kikuchi S.
    Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study.
    Sci Rep. 7:40363, 2017. DOI:10.1038/srep40363
  17. Koyama T, et al.
    Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study.
    BMC Neurol 16(1):253, 2017. DOI:10.1186/s12883-016-0776-z
  18. Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
    PLoS ONE 12(4):e0175649, 2017. DOI:10.1371/journal.pone.0175649
  19. Yamashita T, Kwak S
    [Abnormal RNA editing and treatment strategy in neurological diseases; towards cure for ALS].
    Seikagaku 88:600-608, 2016. DOI:10.14952/SEIKAGAKU.2016.880600
  20. Hayashi H, Ohtani H, Yamaguchi J, Shimokawa I
    A case of malignant transformation of ductal adenoma: a diagnostic pitfall.
    Malays J Pathol 37:281-285, 2016.
  21. Hosono S, Ito H, Oze I, Watanabe M, Komori K, Yatabe Y, Shimizu Y, Tanaka H, Matsuo K
    A risk prediction model for colorectal cancer using genome-wide association study-identified polymorphisms and established risk factors among Japanese: results from two independent case-control studies.
    European journal of cancer prevention 25(6):500-7, 2016. DOI:10.1097/CEJ.0000000000000213
  22. Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H, for the Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group
    ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.
    Nagoya Journal of Medical Science 78(2):183-193, 2016.
  23. Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H; Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.
    ALDH2 polymorphism is independently associated with fasting blood glucose from alcohol consumption in Japanese men.
    Nagoya J Med Sci 78(2):183-193, 2016.
  24. Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurosawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakase Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda M, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J
    Anti-TIF1-γ antibody and cancer-associated myositis:a clinicohistopathological study.
    Neurology 87:299-308, 2016. DOI:10.1212/WNL.0000000000002863
  25. Miyazato P, Katsuya H, Fukuda A, Uchiyama Y, Matsuo M, Tokunaga M, Hino S, Nakao M, Satou Y.
    Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome.
    Sci Rep 6, 2016. DOI:10.1038/srep28324
  26. Shiraishi K, Okada Y, Takahashi A, .., Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T.
    Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
    Nat Commun. 9:12451, 2016. DOI:10.1038/ncomms12451
  27. Nanri H, Nishida Y, Nakamura K, Tanaka K, et al.
    Associations between dietary patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with regard to serum triglyceride levels: J-MICC Study.
    Nutrients 8:545, 2016. DOI:10.3390/nu8090545
  28. Murakami A, Kobayashi D, Kubota T, Zukeyama N, Mukae H, Furusyo N, Kainuma M, Shimazoe T.
    Bioelectrical Impedance Analysis (BIA) of the association of the Japanese Kampo concept "Suidoku" (fluid disturbance) and the body composition of women.
    BMC Complement Altern Med 16:405, 2016. DOI:10.1186/s12906-016-1373-9
  29. Kubota Y, Iso H, Tamakoshi A.
    Bowel Movement Frequency, Laxative Use, and Mortality From Coronary Heart Disease and Stroke Among Japanese Men and Women: The Japan Collaborative Cohort (JACC) Study.
    J Epidemiol 26(5):242-248, 2016. DOI:10.2188/jea.JE20150123
  30. Kadoya M, Hida A, Hashimoto Maeda M, Taira K, Ikenaga C, Uchio N, Kubota A, Kaida K, Miwa Y, Kurasawa K, Shimada H, Sonoo M, Chiba A, Shiio Y, Uesaka Y, Sakurai Y, Izumi T, Inoue M, Kwak S, Tsuji S, Shimizu J.
    Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy .
    Neurol Neuroimmunol Neuroinflamm 3(6):e290. eCollection, 2016. DOI:10.1212/NXI.0000000000000290
  31. Moriuchi H, Yamaguchi J, Hayashi H, Ohtani H, Shimokawa I, Abiru H, Okada H, Eguchi S
    Cancer Cell Interaction with Adipose Tissue: Correlation with the Finding of Spiculation at Mammography.
    Radiology 279:54-64, 2016. DOI:10.1148/radiol.2015142191
  32. 5. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirstr?m K, Pietras K, Blom AM.
    Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.
    Oncogene. 35:5585-5596, 2016. DOI:10.1038/onc.2016.98
  33. Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y, Daigo Y
    Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer.
    Int J Oncol. 49(4):1385-93, 2016. DOI:10.3892/ijo.2016.3649
  34. Baghdad M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino K
    Chemotherapy-induced IL-34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung cancer cells.
    Cancer Research 76:6030-6042, 2016.
  35. Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI
    Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells.
    Cancer Res. 76(20):6030-6042, 2016. DOI:10.1158/0008-5472.CAN-16-1170
  36. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirstr?m K., Orimo A., Jiang WG., Pietras K., Blom AM.,
    Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
    Oncotarget, 7:76920-76933, 2016. DOI:10.18632/oncotarget.12729
  37. Tatsuhiro Terada, Tomokazu Obi, Jun Miyata, Manabu Kubota, Miho Yoshizumi, Toshiya Murai, Kinya Yamazaki and Kouichi Mizoguchi
    Correlation of frontal atrophy with behavioral changes in amyotrophic lateral sclerosis.
    Neurology and Clinical Neuroscience 4(3):85-92, 2016. DOI:10.1111/ncn3.12046
  38. Wada S, Yada E, Ohtake J, Fujimoto Y, Uchiyama H, Yoshida S, Sasada T.
    Current status and future prospects of peptide-based cancer vaccines.
    Immunotherapy 8(11):1321-1333, 2016. DOI:10.2217/imt-2016-0063
  39. Wada A, Kunii Y, Matsumoto J, Hino M, Nagaoka A, Niwa SI, Yabe H
    Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia.
    Neuropsychiatr Dis Treat 12:1645-1650, 2016. DOI:10.2147/NDT.S106371
  40. Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H.
    Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
    J Psychiatr Res. 82:100-8, 2016. DOI:10.1016/j.jpsychires.2016.07.018
  41. Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa SI, Nawa H, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H
    Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
    J Psychiatr Res 82:100-108, 2016. DOI:10.1016/j.jpsychires.2016.07.018
  42. Aizawa H, Hideyama T, Yamashita T, Kimura T, Suzuki N, Aoki M, Kwak S
    Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUSP525L mutation.
    Journal of Clinical Neuroscience 32:128-129, 2016. DOI:10.1016/j.jocn.2015.12.039
  43. Tan C, Mori M, Adachi Y, Wakai K, Suzuki S, Suzuki K, Hashimoto Sh, Watanabe Y, Tamakoshi A.
    Diabetes Mellitus and Risk of Colorectal Cancer Mortality in Japan: the Japan Collaborative Cohort Study.
    Asian Pacific Journal of Cancer Prevention 17(10):4681-4688, 2016. DOI:10.22034/APJCP.2016.17.10.4681
  44. Nakano K, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T.
    Dysregulation of c-Myb pathway by aberrant expression of proto-oncogene MYB provides the basis for malignancy in adult T-cell leukemia/lymphoma cells.
    Clin Cancer Res. 22(23):5915-5923, 2016. DOI:10.1158/1078-0432.CCR-15-1739
  45. Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, Hara M, Suzuki S, Hosono S, Takashima N, Ohnaka K, Takada A, Mikami H, Watanabe Y, Uemura H, Kubo M, Tanaka H
    Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.
    Gene 594:16-22, 2016. DOI:10.1016/j.gene.2016.08.051
  46. Hiwasa T, Zhang XM, Kimura R, Ohno M, Chen PM, Nishi E, Ono K, Kimura T, Kamitsukasa I, Wada T, Aotsuka A, Mine S, Takizawa H, Kashiwado K, Takemoto M, Kobayashi K, Kawamura H, Ishibashi R, Yokote K, Nakamura R, Tomiyoshi G, Shinmen N, Kuroda H.
    Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus.
    Journal of Circulating Biomarkers 5:8, 2016. DOI:10.5772/63218
  47. Ikezaki H, Ai M, Schaefer E J, Otokozawa S, Asztalos B F, Nakajima K, Zhou Y, Liu C T, Jacques P F, Cupples L A, Furusyo N.
    Ethnic Differences in Glucose Homeostasis Markers between the Kyushu-Okinawa Population Study and the Framingham Offspring Study.
    Sci Rep 6:36725, 2016. DOI:10.1038/srep36725
  48. Satoh J, Kino Y, Yanaizu M, Tosaki Y, Sakai K, Ishida T, Saito Y.
    Expression of gp91phox and p22phox, catalytic subunits of NADPH oxidase, on microglia in Nasu-Hakola disease brains.
    Intractable & Rare Diseases Research 5:275-279, 2016. DOI:10.5582/irdr.2016.01086
  49. Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
    Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
    NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13
  50. Tatsuhiro Terada, Masamichi Yokokura, Etsuji Yoshikawa, Masami Futatsubashi, Satoshi Kono, Takashi Konishi, Hiroaki Miyajima, Takanori Hashizume, Yasuomi Ouchi
    Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study.
    Ann Nucl Med. 30(8):579-87, 2016. DOI:10.1007/s12149-016-1099-2
  51. Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Shimokawa I, Mori N, FuruyamaT
    FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction.
    Mol Cell Biochem 412:119-130, 2016. DOI:10.1007/s11010-015-2615-8
  52. Fujita, K., Motoki, K., Tagawa, K., (他13名), Okazawa, H.
    HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease.
    Scientific Reports 6:31895, 2016. DOI:10.1038/srep31895
  53. Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N.
    Identification of novel biomarkers for Parkinson's disease by metabolomic technologies.
    J Neurol Neurosurg Psychiatry. 87:295-301, 2016. DOI:10.1136/jnnp-2014-309676
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    IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy .
    J Neuroimmunol 16:30267-3, 2016. DOI:10.1016/j.jneuroim.2016.10.013
  55. Sasada T, Azuma K, Ohtake J, Fujimoto Y.
    Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment.
    Front Pharmacol. 7:405, 2016. DOI:10.3389/fphar.2016.00405
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    Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease.
    J Neurol Sci. 365:101-107, 2016. DOI:10.1016/j.jns.2016.03.035
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    Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study.
    Tumour Biol 37:15125-15132, 2016.
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    Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study.
    Tumour Biol. 37:15125-15132, 2016. DOI:10.1007/s13277-016-5360-z
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    Intensity-specific effect of physical activity on urinary levels of 8-hydroxydeoxyguanosine in middle-aged Japanese.
    Cancer Science 107:1653-1659, 2016. DOI:10.1111/cas.13070
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    Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase C?-dependent manner.
    J Biol Chem 291(24):12573, 2016. DOI:10.1074/jbc.A109.025940
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    Lection inhibits antigen-antibody reaction in a glycoform-specific manner: Application for detecting a2,6sialylated-carcinoembryonic antigen.
    Proteomics 16:3081-3084, 2016. DOI:10.1002/pmic.201600117
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    Levels of immunoglobulin E specific to the major food allergen and chemokine (C-C motif) ligand (CCL)17/thymus and activation regulated chemokine and CCL22/macrophage-derived chemokine in infantile atopic dermatitis on Ishigaki Island.
    J Dermatol 43:1278-1282, 2016. DOI:10.1111/1346-8138.13360
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    Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
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    Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.
    Sci Rep 6:23281, 2016. DOI:10.1038/srep23281
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    Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.
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